Changes in Blood Coagulation

Changes in blood coagulation.

Changes in blood coagulation-related parameters in phenobarbital-treated rabbits.

The effects of repeated administration of phenobarbital (PB) on blood coagulation time were examined using male Japanese white SPF rabbits, which are widely used for toxicological studies. PB was administered to the rabbits by oral gavage for 2 weeks, at dose levels of 0, 12.5, 25 and 50 mg/kg/day. Blood was collected on Days 8 and 14 after each day's dosing to perform blood coagulation examina...

Blood Coagulation Changes in Rats Fed High Fat Diets.

• For the past fift3 j-ears investigators have attempted to show a relationship between high lipid diets and the production of atherosclerosis and thrombosis. Recently interest has shifted from a consideration of diets in the pathogenesis of atherosclerosis to a study of their association with alterations in the levels of coagulation factors as a possible cause of thrombus formation, a possibil...

Studies in Blood Coagulation

Description is given of changes in blood coagulability found in diseases of the rabbit, including malignant tumor, spontaneous infections, non-bacterial diseases and lesions, and hemorrhagic states specifically induced. The changes involved variously the time of onset of blood coagulation, clot formation rate and the rate and extent of clot retraction.

Coagulation in Embryonic Blood

1. In pig embryos of 100 to 270 mm. the average coagulation time of the blood was found to be about 23 minutes. This represents a coagulation time six to eight times greater than that obtained for the adult. 2. The first evidence of coagulation in the blood of these embryos consisted in the appearance of small masses of fibrin deposited almost invariably at the side of the test-tube. The ensuin...